Wednesday 7 October 2015

Cannabis - All Research

A very big thank you to Matt Aldridge for putting this information together

Please Support #EndOurPain for legal access to cannabis as a medicine.
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Scientific Studies from the National Institute of Health

If you’re still in doubt regarding the potential of cannabis in the treatment of cancer, have a look at these 100+ scientific studies from the National Institute of Health:
Cannabis kills tumour cells
Uterine, testicular, and pancreatic cancers
Brain cancer
Mouth and throat cancer
Breast cancer
Lung cancer
Prostate cancer
Blood cancer
Skin cancer
Liver cancer
Cannabis and cancer (general)
Cancers of the head and neck
Cholangiocarcinoma cancer
Leukemia
Cannabis partially/fully induced cancer cell death
Translocation-positive rhabdomyosarcoma
Lymphoma
Cannabis kills cancer cells
Melanoma
Thyroid carcinoma
Colon cancer
Intestinal inflammation and cancer
Cannabinoids in health and disease
Cannabis inhibits cancer cell invasion
GERMANY
Pharmacokinetics and pharmacodynamics of cannabinoids.
http://www.ncbi.nlm.nih.gov/pubmed/12648025
Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1.
http://www.ncbi.nlm.nih.gov/pubmed/19914218
Cannabinoids induce cancer cell proliferation via tumor necrosis factor alpha-converting enzyme (TACE/ADAM17)-mediated transactivation of the epidermal growth factor receptor.
http://www.ncbi.nlm.nih.gov/pubmed/15026328
Cannabinoid receptors in human astroglial tumors.
http://www.ncbi.nlm.nih.gov/pubmed/16893424
Up-regulation of cyclooxygenase-2 expression is involved in R(+)-methanandamide-induced apoptotic death of human neuroglioma cells.
http://www.ncbi.nlm.nih.gov/pubmed/15361550
Antitumorigenic effects of cannabinoids beyond apoptosis.
http://www.ncbi.nlm.nih.gov/pubmed/19889794
R(+)-methanandamide-induced apoptosis of human cervical carcinoma cells involves a cyclooxygenase-2-dependent pathway.
http://www.ncbi.nlm.nih.gov/pubmed/19015962
HUNGARY
The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities.
http://www.ncbi.nlm.nih.gov/pubmed/19608284
ISRAEL
HU-331, a novel cannabinoid-based anticancer topoisomerase II inhibitor.
http://www.ncbi.nlm.nih.gov/pubmed/17237277
An endogenous cannabinoid (2-AG) is neuroprotective after brain injury.
http://www.ncbi.nlm.nih.gov/pubmed/11586361
Gamma-irradiation enhances apoptosis induced by cannabidiol, a non-psychotropic cannabinoid, in cultured HL-60 myeloblastic leukemia cells.
http://www.ncbi.nlm.nih.gov/pubmed/14692532
A cannabinoid quinone inhibits angiogenesis by targeting vascular endothelial cells.
http://www.ncbi.nlm.nih.gov/pubmed/16571653
Cannabinoids in health and disease.
http://www.ncbi.nlm.nih.gov/pubmed/18286801
Cannabinoids and cancer.
http://www.ncbi.nlm.nih.gov/pubmed/16250836
Delta 9-tetrahydrocannabinol inhibits cell cycle progression by downregulation of E2F1 in human glioblastoma multiforme cells.
http://www.ncbi.nlm.nih.gov/pubmed/17934890
ITALY
Endocannabinoids in the immune system and cancer.
http://www.ncbi.nlm.nih.gov/pubmed/12052046
A metabolically stable analogue of anandamide, Met-F-AEA, inhibits human thyroid carcinoma cell lines by activation of apoptosis.
http://www.ncbi.nlm.nih.gov/pubmed/19189054
Plant-derived cannabinoids modulate the activity of transient receptor potential channels of ankyrin type-1 and melastatin type-8.
http://www.ncbi.nlm.nih.gov/pubmed/18354058
Cannabinoid receptor activation induces apoptosis through tumor necrosis factor alpha-mediated ceramide de novo synthesis in colon cancer cells.
http://www.ncbi.nlm.nih.gov/pubmed/19047095
Anandamide induces apoptosis in human cells via vanilloid receptors. Evidence for a protective role of cannabinoid receptors.
http://www.ncbi.nlm.nih.gov/pubmed/10913156
The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation.
http://www.ncbi.nlm.nih.gov/pubmed/9653194
Cannabinoids as potential new therapy for the treatment of gliomas.
http://www.ncbi.nlm.nih.gov/pubmed/18088200
The non-psychoactive cannabidiol triggers caspase activation and oxidative stress in human glioma cells.
http://www.ncbi.nlm.nih.gov/pubmed/16909207
Endocannabinoids as emerging suppressors of angiogenesis and tumor invasion (review).
http://www.ncbi.nlm.nih.gov/pubmed/17342320
Apoptosis induced in HepG2 cells by the synthetic cannabinoid WIN: involvement of the transcription factor PPARgamma.
http://www.ncbi.nlm.nih.gov/pubmed/19059457
[The endocannabinoid system as a target for the development of new drugs for cancer therapy].
http://www.ncbi.nlm.nih.gov/pubmed/12723496
Cannabinoids in intestinal inflammation and cancer.
http://www.ncbi.nlm.nih.gov/pubmed/19442536
Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma.
http://www.ncbi.nlm.nih.gov/pubmed/16728591
The CB1/CB2 receptor agonist WIN-55,212-2 reduces viability of human Kaposi's sarcoma cells in vitro.
http://www.ncbi.nlm.nih.gov/pubmed/19539619
Cannabinoid derivatives induce cell death in pancreatic MIA PaCa-2 cells via a receptor-independent mechanism.
http://www.ncbi.nlm.nih.gov/pubmed/16500647
The endocannabinoid anandamide neither impairs in vitro T-cell function nor induces regulatory T-cell generation.
http://www.ncbi.nlm.nih.gov/pubmed/19189659
Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines.
http://www.ncbi.nlm.nih.gov/pubmed/14617682
Estrogenic induction of cannabinoid CB1 receptor in human colon cancer cell lines.
http://www.ncbi.nlm.nih.gov/pubmed/18938775
Endocannabinoids and fatty acid amides in cancer, inflammation and related disorders.
http://www.ncbi.nlm.nih.gov/pubmed/11106791
JAPAN
Pharmacological synergism between cannabinoids and paclitaxel in gastric cancer cell lines.
http://www.ncbi.nlm.nih.gov/pubmed/19394652
KOREA
Effect of a synthetic cannabinoid agonist on the proliferation and invasion of gastric cancer cells.
http://www.ncbi.nlm.nih.gov/pubmed/20336665
NEW ZEALAND
Cannabinoids in the treatment of cancer.
http://www.ncbi.nlm.nih.gov/pubmed/19442435
POLAND
Cannabinoids down-regulate PI3K/Akt and Erk signalling pathways and activate proapoptotic function of Bad protein.
http://www.ncbi.nlm.nih.gov/pubmed/15451022
SAUDI ARABIA
Cannabinoid 2 receptor induction by IL-12 and its potential as a therapeutic target for the treatment of anaplastic thyroid carcinoma.
http://www.ncbi.nlm.nih.gov/pubmed/18197164
SLOVAKIA
[Different views on the association between cannabinoids and cancer].
http://www.ncbi.nlm.nih.gov/pubmed/16835997
SPAIN
De novo-synthesized ceramide is involved in cannabinoid-induced apoptosis.
http://www.ncbi.nlm.nih.gov/pubmed/11903061
Down-regulation of tissue inhibitor of metalloproteinases-1 in gliomas: a new marker of cannabinoid antitumoral activity?
http://www.ncbi.nlm.nih.gov/pubmed/17675107
Cannabinoids induce glioma stem-like cell differentiation and inhibit gliomagenesis.
http://www.ncbi.nlm.nih.gov/pubmed/17202146
Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells.
http://www.ncbi.nlm.nih.gov/pubmed/19425170
JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells.
http://www.ncbi.nlm.nih.gov/pubmed/18454173
Cannabinoid receptors as novel targets for the treatment of melanoma.
http://www.ncbi.nlm.nih.gov/pubmed/17065222
Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation.
http://www.ncbi.nlm.nih.gov/pubmed/10700234
Endocannabinoids: a new family of lipid mediators involved in the regulation of neural cell development.
http://www.ncbi.nlm.nih.gov/pubmed/16787257
Cannabinoids and ceramide: two lipids acting hand-by-hand.
http://www.ncbi.nlm.nih.gov/pubmed/15958274
p38 MAPK is involved in CB2 receptor-induced apoptosis of human leukaemia cells.
http://www.ncbi.nlm.nih.gov/pubmed/16139274
The CB2 cannabinoid receptor signals apoptosis via ceramide-dependent activation of the mitochondrial intrinsic pathway.
http://www.ncbi.nlm.nih.gov/pubmed/16624285
The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells.
http://www.ncbi.nlm.nih.gov/pubmed/16616335
Control of the cell survival/death decision by cannabinoids.
http://www.ncbi.nlm.nih.gov/pubmed/11269508
Inhibition of human tumour prostate PC-3 cell growth by cannabinoids R(+)-Methanandamide and JWH-015: involvement of CB2.
http://www.ncbi.nlm.nih.gov/pubmed/19690545
Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors.
http://www.ncbi.nlm.nih.gov/pubmed/12511587
Opposite changes in cannabinoid CB1 and CB2 receptor expression in human gliomas.
http://www.ncbi.nlm.nih.gov/pubmed/20307616
Delta9-tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through Cdc2 regulation.
http://www.ncbi.nlm.nih.gov/pubmed/16818634
Cannabinoids and gliomas.
http://www.ncbi.nlm.nih.gov/pubmed/17952650
Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes.
http://www.ncbi.nlm.nih.gov/pubmed/16818650
Effects on cell viability.
http://www.ncbi.nlm.nih.gov/pubmed/16596790
Involvement of cannabinoids in cellular proliferation.
http://www.ncbi.nlm.nih.gov/pubmed/15638794
Hypothesis: cannabinoid therapy for the treatment of gliomas?
http://www.ncbi.nlm.nih.gov/pubmed/15275820
Cannabinoids protect astrocytes from ceramide-induced apoptosis through the phosphatidylinositol 3-kinase/protein kinase B pathway.
http://www.ncbi.nlm.nih.gov/pubmed/12133838
Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression.
http://www.ncbi.nlm.nih.gov/pubmed/18339876
Delta9-tetrahydrocannabinol induces apoptosis in C6 glioma cells.
http://www.ncbi.nlm.nih.gov/pubmed/9771884
Delta9-tetrahydrocannabinol induces apoptosis in human prostate PC-3 cells via a receptor-independent mechanism.
http://www.ncbi.nlm.nih.gov/pubmed/10570948
Cannabinoids and cell fate.
http://www.ncbi.nlm.nih.gov/pubmed/12182964
Amphiregulin is a factor for resistance of glioma cells to cannabinoid-induced apoptosis.
http://www.ncbi.nlm.nih.gov/pubmed/19229996
SWEDEN
Potentiation of cannabinoid-induced cytotoxicity in mantle cell lymphoma through modulation of ceramide metabolism.
http://www.ncbi.nlm.nih.gov/pubmed/19609004
Cannabinoid receptor ligands mediate growth inhibition and cell death in mantle cell lymphoma.
http://www.ncbi.nlm.nih.gov/pubmed/16337199
Cannabinoid receptor-mediated apoptosis induced by R(+)-methanandamide and Win55,212-2 is associated with ceramide accumulation and p38 activation in mantle cell lymphoma.
http://www.ncbi.nlm.nih.gov/pubmed/16936228
Expression of cannabinoid receptors type 1 and type 2 in non-Hodgkin lymphoma: growth inhibition by receptor activation.
http://www.ncbi.nlm.nih.gov/pubmed/18546271
SWITZERLAND
Arachidonylethanolamide induces apoptosis of human glioma cells through vanilloid receptor-1.
http://www.ncbi.nlm.nih.gov/pubmed/15453094
Cannabinoid receptor ligands as potential anticancer agents--high hopes for new therapies?
http://www.ncbi.nlm.nih.gov/pubmed/19589225
Arachidonyl ethanolamide induces apoptosis of uterine cervix cancer cells via aberrantly expressed vanilloid receptor-1.
http://www.ncbi.nlm.nih.gov/pubmed/15047233
Cannabinoid receptor 1 is a potential drug target for treatment of translocation-positive rhabdomyosarcoma.
http://www.ncbi.nlm.nih.gov/pubmed/19509271
Predominant CB2 receptor expression in endothelial cells of glioblastoma in humans.
http://www.ncbi.nlm.nih.gov/pubmed/19480992
TAIWAN
A comparative study on cannabidiol-induced apoptosis in murine thymocytes and EL-4 thymoma cells.
http://www.ncbi.nlm.nih.gov/pubmed/18387516
THAILAND
The dual effects of delta(9)-tetrahydrocannabinol on cholangiocarcinoma cells: anti-invasion activity at low concentration and apoptosis induction at high concentration.
http://www.ncbi.nlm.nih.gov/pubmed/19916793
UKRAINE
Antineoplastic and apoptotic effects of cannabinoids. N-acylethanolamines: protectors or killers?
http://www.ncbi.nlm.nih.gov/pubmed/18438336
UNITED KINGDOM
Cannabis-induced cytotoxicity in leukemic cell lines: the role of the cannabinoid receptors and the MAPK pathway.
http://www.ncbi.nlm.nih.gov/pubmed/15454482
The cannabinoid delta(9)-tetrahydrocannabinol inhibits RAS-MAPK and PI3K-AKT survival signalling and induces BAD-mediated apoptosis in colorectal cancer cells.
http://www.ncbi.nlm.nih.gov/pubmed/17583570
Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death.
http://www.ncbi.nlm.nih.gov/pubmed/17931597
High concentrations of cannabinoids activate apoptosis in human U373MG glioma cells.
http://www.ncbi.nlm.nih.gov/pubmed/18615640
Cannabinoid receptor systems: therapeutic targets for tumour intervention.
http://www.ncbi.nlm.nih.gov/pubmed/14640910
UNITED STATES OF AMERICA
Cannabinoids as novel anti-inflammatory drugs.
http://www.ncbi.nlm.nih.gov/pubmed/20191092
Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells.
http://www.ncbi.nlm.nih.gov/pubmed/18025276
In vivo effects of cannabinoids on macromolecular biosynthesis in Lewis lung carcinomas.
http://www.ncbi.nlm.nih.gov/pubmed/616322
Cannabinoid receptor as a novel target for the treatment of prostate cancer.
http://www.ncbi.nlm.nih.gov/pubmed/15753356
Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease.
http://www.ncbi.nlm.nih.gov/pubmed/12091357
Cannabinoids for cancer treatment: progress and promise.
http://www.ncbi.nlm.nih.gov/pubmed/18199524
Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancer.
http://www.ncbi.nlm.nih.gov/pubmed/19887554
Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression.
http://www.ncbi.nlm.nih.gov/pubmed/19457575
Delta9-tetrahydrocannabinol-induced apoptosis in Jurkat leukemia T cells is regulated by translocation of Bad to mitochondria.
http://www.ncbi.nlm.nih.gov/pubmed/16908594
Delta(9)-tetrahydrocannabinol-induced apoptosis in the thymus and spleen as a mechanism of immunosuppression in vitro and in vivo.
http://www.ncbi.nlm.nih.gov/pubmed/12130702
Cannabinoids and the immune system.
http://www.ncbi.nlm.nih.gov/pubmed/11854771
Cannabidiol enhances the inhibitory effects of delta9-tetrahydrocannabinol on human glioblastoma cell proliferation and survival.
http://www.ncbi.nlm.nih.gov/pubmed/20053780
Cannabidiol-induced apoptosis in human leukemia cells: A novel role of cannabidiol in the regulation of p22phox and Nox4 expression.
http://www.ncbi.nlm.nih.gov/pubmed/16754784
The expression level of CB1 and CB2 receptors determines their efficacy at inducing apoptosis in astrocytomas.
http://www.ncbi.nlm.nih.gov/pubmed/20090845
Targeting cannabinoid receptors to treat leukemia: role of cross-talk between extrinsic and intrinsic pathways in Delta9-tetrahydrocannabinol (THC)-induced apoptosis of Jurkat cells.
http://www.ncbi.nlm.nih.gov/pubmed/15978942

Jon Liebling – Political Director of United Patients Alliance
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